Motif ID: HOX{A5,B5}.p2

Z-value: 0.913


Transcription factors associated with HOX{A5,B5}.p2:

Gene SymbolEntrez IDGene Name
HOXA5 3202 homeobox A5
HOXB5 3215 homeobox B5

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HOXB5chr17_-_466713220.384.0e-02Click!
HOXA5chr7_-_271832250.048.2e-01Click!


Activity profile for motif HOX{A5,B5}.p2.

activity profile for motif HOX{A5,B5}.p2


Sorted Z-values histogram for motif HOX{A5,B5}.p2

Sorted Z-values for motif HOX{A5,B5}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A5,B5}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_112970412 3.359 NM_001012993
C9orf152
chromosome 9 open reading frame 152
chr16_-_67427335 2.636 NM_015964
NM_016140
TPPP3

tubulin polymerization-promoting protein family member 3

chr5_-_35938736 1.951 NM_001042625
NM_144647
CAPSL

calcyphosine-like

chr4_-_149363498 1.877 NM_000901
NM_001166104
NR3C2

nuclear receptor subfamily 3, group C, member 2

chr19_+_51152634 1.851 NM_001195076
C19orf81
chromosome 19 open reading frame 81
chr16_+_71560022 1.675 NM_005769
NM_001166395
CHST4

carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4

chr2_+_8822112 1.620 NM_002166
ID2
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
chr13_-_39564857 1.492 NM_001144033
NM_145286
STOML3

stomatin (EPB72)-like 3

chr4_+_55523906 1.476 NM_000222
NM_001093772
KIT

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

chr19_+_41515495 1.465 CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr1_+_162351519 1.358 NM_001085375
C1orf226
chromosome 1 open reading frame 226
chr12_+_7013896 1.355 NM_001135217
NM_006992
NM_201650
LRRC23


leucine rich repeat containing 23


chr3_-_46506342 1.195 NM_002343
LTF
lactotransferrin
chr10_+_114136014 0.987 ACSL5
acyl-CoA synthetase long-chain family member 5
chr22_-_36556781 0.945 NM_145640
APOL3
apolipoprotein L, 3
chr11_-_62472901 0.892


chr9_-_28719302 0.803 NM_152570
LINGO2
leucine rich repeat and Ig domain containing 2
chr11_-_2019007 0.797 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr19_+_8274179 0.780 NM_024552
CERS4
ceramide synthase 4
chr10_+_114135937 0.779 NM_016234
ACSL5
acyl-CoA synthetase long-chain family member 5
chr9_+_42717233 0.766 NM_001099279
NM_199244
FOXD4L2
FOXD4L4
forkhead box D4-like 2
forkhead box D4-like 4
chr8_-_143999255 0.764 NM_000498
CYP11B2
cytochrome P450, family 11, subfamily B, polypeptide 2
chr6_-_29527477 0.749 UBD
ubiquitin D
chr7_+_5322553 0.721 NM_001040661
NM_153247
SLC29A4

solute carrier family 29 (nucleoside transporters), member 4

chr17_-_41985112 0.717 NM_005374
MPP2
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
chr1_-_41157708 0.700 LOC100130557
uncharacterized LOC100130557
chr10_+_114135965 0.678 ACSL5
acyl-CoA synthetase long-chain family member 5
chr14_-_100625931 0.673 NM_206918
DEGS2
delta(4)-desaturase, sphingolipid 2
chr1_-_161337663 0.648 NM_001013625
C1orf192
chromosome 1 open reading frame 192
chr9_-_70178814 0.624 NM_001126334
FOXD4L5
forkhead box D4-like 5
chr9_-_70429730 0.620 NM_001099279
NM_199244
FOXD4L2
FOXD4L4
forkhead box D4-like 2
forkhead box D4-like 4
chr1_+_41157493 0.619 NFYC
nuclear transcription factor Y, gamma
chr16_-_1821709 0.615 NM_002513
NME3
non-metastatic cells 3, protein expressed in
chr17_-_41984888 0.586 MPP2
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
chr14_+_21498344 0.579 NM_173846
TPPP2
tubulin polymerization-promoting protein family member 2
chr22_+_25591072 0.579 KIAA1671
KIAA1671
chr2_-_217540722 0.563 IGFBP5
insulin-like growth factor binding protein 5
chr11_-_114271052 0.555 NM_019021
C11orf71
chromosome 11 open reading frame 71
chr1_+_20512577 0.553 NM_152376
UBXN10
UBX domain protein 10
chr15_+_74218811 0.550 LOXL1
lysyl oxidase-like 1
chr16_-_28634873 0.550 NM_177536
SULT1A1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr2_+_102770401 0.547 NM_000877
IL1R1
interleukin 1 receptor, type I
chr6_-_46922533 0.544 NM_015234
GPR116
G protein-coupled receptor 116
chr11_+_36317724 0.529 NM_001160167
PRR5L
proline rich 5 like
chr9_-_4152182 0.527 NM_152629
GLIS3
GLIS family zinc finger 3
chr15_+_74218794 0.524 LOXL1
lysyl oxidase-like 1
chr15_+_74218786 0.519 NM_005576
LOXL1
lysyl oxidase-like 1
chr1_+_158259558 0.517 NM_001765
CD1C
CD1c molecule
chr12_+_50497790 0.517 NM_005276
GPD1
glycerol-3-phosphate dehydrogenase 1 (soluble)
chr11_-_57283145 0.506 NM_003627
SLC43A1
solute carrier family 43, member 1
chr16_-_27899477 0.502 NM_144675
GSG1L
GSG1-like
chr2_-_74644843 0.498 NM_001145054
C2orf81
chromosome 2 open reading frame 81
chr6_-_24877453 0.493 NM_015864
FAM65B
family with sequence similarity 65, member B
chr11_-_106888829 0.489 NM_000855
GUCY1A2
guanylate cyclase 1, soluble, alpha 2
chr5_+_149569519 0.483 NM_014228
SLC6A7
solute carrier family 6 (neurotransmitter transporter, L-proline), member 7
chr8_-_95229530 0.474 NM_001144663
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr1_-_146696896 0.473 FMO5
flavin containing monooxygenase 5
chr22_-_37608352 0.463 NM_001051
SSTR3
somatostatin receptor 3
chr1_+_41157646 0.463 NM_001142590
NFYC
nuclear transcription factor Y, gamma
chr16_-_1821503 0.457 NME3
non-metastatic cells 3, protein expressed in
chr13_-_49107250 0.455 NM_001268
RCBTB2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr3_-_121379757 0.454 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr6_-_46620229 0.450 NM_016593
CYP39A1
cytochrome P450, family 39, subfamily A, polypeptide 1
chr4_+_70861647 0.449 NM_001009181
NM_003154
STATH

statherin

chr4_+_15480833 0.448 CC2D2A
coiled-coil and C2 domain containing 2A
chr8_+_21916858 0.440 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr11_-_2018334 0.413 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr9_-_92112887 0.412 SEMA4D
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
chr22_+_31003069 0.412 NM_000355
NM_001184726
TCN2

transcobalamin II

chr1_+_41157349 0.410 NFYC
nuclear transcription factor Y, gamma
chr9_+_4662285 0.409 NM_203453
PPAPDC2
phosphatidic acid phosphatase type 2 domain containing 2
chr6_+_36916038 0.409 NM_001199159
PI16
peptidase inhibitor 16
chr1_+_41157475 0.407 NFYC
nuclear transcription factor Y, gamma
chr11_-_2018885 0.405 H19
RPS12
H19, imprinted maternally expressed transcript (non-protein coding)
ribosomal protein S12
chr11_-_111782447 0.405 NM_001885
CRYAB
crystallin, alpha B
chr1_-_1310522 0.401 AURKAIP1
aurora kinase A interacting protein 1
chr22_-_50746000 0.400 NM_012401
PLXNB2
plexin B2
chr5_+_133842276 0.397


chr1_+_41157428 0.390 NFYC
nuclear transcription factor Y, gamma
chr2_+_98330030 0.389 NM_001079
ZAP70
zeta-chain (TCR) associated protein kinase 70kDa
chr9_+_70917782 0.385 NM_199135
FOXD4L3
FOXD4L6
forkhead box D4-like 3
forkhead box D4-like 6
chr1_+_41157392 0.383 NFYC
nuclear transcription factor Y, gamma
chr13_-_49107357 0.383 RCBTB2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr8_+_21916685 0.380 NM_001114138
NM_001978
EPB49

erythrocyte membrane protein band 4.9 (dematin)

chr1_+_116915881 0.378 ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr1_+_41157406 0.372 NFYC
nuclear transcription factor Y, gamma
chr17_+_73598139 0.370 MYO15B
myosin XVB pseudogene
chr8_-_141467810 0.369 TRAPPC9
trafficking protein particle complex 9
chr17_+_78161598 0.367 NM_052819
CARD14
caspase recruitment domain family, member 14
chr6_+_31868775 0.362 NM_001178063
C2
complement component 2
chr1_+_116916029 0.360 ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr13_-_114538953 0.353 NM_001143945
GAS6
growth arrest-specific 6
chr15_+_43809805 0.353 NM_002373
MAP1A
microtubule-associated protein 1A
chr1_-_26644755 0.350 NM_145345
UBXN11
UBX domain protein 11
chr11_+_61976139 0.349 NM_002407
SCGB2A1
secretoglobin, family 2A, member 1
chr1_-_23810627 0.347 ASAP3
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
chr11_+_71900601 0.347 NM_016724
NM_016725
FOLR1

folate receptor 1 (adult)

chr8_-_141467853 0.347 NM_001160372
TRAPPC9
trafficking protein particle complex 9
chr6_-_29595746 0.346 GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr6_-_32557431 0.345 NM_001243965
NM_002124
HLA-DRB1

HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1

major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr17_-_34328607 0.345 CCL14-CCL15
CCL14-CCL15 readthrough
chr2_-_88427535 0.341 NM_001443
FABP1
fatty acid binding protein 1, liver
chr22_-_22901421 0.338 NM_206955
NM_206956
NM_006115
NM_206953
NM_206954
PRAME




preferentially expressed antigen in melanoma




chr1_-_75139421 0.336 NM_001002912
C1orf173
chromosome 1 open reading frame 173
chr20_-_1638359 0.332 NM_001039508
NM_018556
NM_080816
SIRPG


signal-regulatory protein gamma


chr12_-_91572328 0.331 NM_133504
NM_133505
NM_133506
NM_133507
DCN



decorin



chr1_+_4714668 0.329 AJAP1
adherens junctions associated protein 1
chr14_-_23284565 0.328 SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr7_+_142960502 0.325 NM_001143679
NM_001143680
NM_001143681
NM_015917
GSTK1



glutathione S-transferase kappa 1



chr1_+_116916488 0.323 NM_001160233
ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr1_+_116915938 0.323 ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr19_+_54057898 0.322 NM_001253801
ZNF331
zinc finger protein 331
chr6_+_16129321 0.321 MYLIP
myosin regulatory light chain interacting protein
chr17_-_46894380 0.318 NM_001130918
TTLL6
tubulin tyrosine ligase-like family, member 6
chr6_-_29527701 0.316 NM_006398
UBD
ubiquitin D
chrM_+_12283 0.312


chrX_+_128872924 0.307 NM_003399
XPNPEP2
X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
chrX_+_119029799 0.303 NM_001008534
NM_001008535
NM_178813
AKAP14


A kinase (PRKA) anchor protein 14


chr16_-_58005011 0.300 NM_001135639
NM_001297
CNGB1

cyclic nucleotide gated channel beta 1

chr20_+_31823801 0.299 NM_001243193
NM_016583
NM_130852
BPIFA1


BPI fold containing family A, member 1


chr1_+_32930638 0.293 NM_001145720
ZBTB8B
zinc finger and BTB domain containing 8B
chrX_-_119603068 0.293 LAMP2
lysosomal-associated membrane protein 2
chrX_-_119603136 0.293 LAMP2
lysosomal-associated membrane protein 2
chr3_+_23986735 0.292 NM_005126
NR1D2
nuclear receptor subfamily 1, group D, member 2
chr11_-_2018446 0.292 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr20_+_3024267 0.291 NM_001501
NM_178331
NM_178332
GNRH2


gonadotropin-releasing hormone 2


chr19_-_42348507 0.285 NM_173506
LYPD4
LY6/PLAUR domain containing 4
chr3_-_164914448 0.279 NM_014926
SLITRK3
SLIT and NTRK-like family, member 3
chr10_+_102295700 0.278 HIF1AN
hypoxia inducible factor 1, alpha subunit inhibitor
chr9_-_69202203 0.277 NM_001085476
FOXD4L6
forkhead box D4-like 6
chr9_-_135819953 0.277 TSC1
tuberous sclerosis 1
chr22_-_39190146 0.274 NM_005740
DNAL4
dynein, axonemal, light chain 4
chr11_-_62474869 0.274 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr11_-_8954534 0.273 NM_020643
C11orf16
chromosome 11 open reading frame 16
chr5_-_149535138 0.269 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr1_-_23810721 0.267 NM_001143778
NM_017707
ASAP3

ArfGAP with SH3 domain, ankyrin repeat and PH domain 3

chr16_+_57769626 0.265 NM_005886
KATNB1
katanin p80 (WD repeat containing) subunit B 1
chr16_-_57570455 0.263 NM_033212
CCDC102A
coiled-coil domain containing 102A
chr12_+_108909049 0.263 NM_007076
FICD
FIC domain containing
chr1_-_120935943 0.261 NM_001004340
NM_001017986
NM_001244910
FCGR1A
FCGR1B


Fc fragment of IgG, high affinity Ia, receptor (CD64)
Fc fragment of IgG, high affinity Ib, receptor (CD64)


chr16_+_89686999 0.260 NM_004413
DPEP1
dipeptidase 1 (renal)
chr11_-_62474810 0.258 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chrX_+_105412297 0.256 NM_001171020
NM_152423
MUM1L1

melanoma associated antigen (mutated) 1-like 1

chr1_-_144994908 0.255 PDE4DIP
phosphodiesterase 4D interacting protein
chrX_+_140982451 0.255 NM_177456
MAGEC3
melanoma antigen family C, 3
chr1_-_117746457 0.254 NM_001253849
VTCN1
V-set domain containing T cell activation inhibitor 1
chrX_-_100307042 0.253 TRMT2B
TRM2 tRNA methyltransferase 2 homolog B (S. cerevisiae)
chr14_-_23285011 0.251 NM_001126105
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr16_+_58283819 0.251 NM_001142302
NM_014157
CCDC113

coiled-coil domain containing 113

chr21_+_42676176 0.249 FAM3B
family with sequence similarity 3, member B
chr17_-_74639719 0.247 NM_018414
ST6GALNAC1
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
chrX_+_114524291 0.246 NM_016383
LUZP4
leucine zipper protein 4
chr19_-_291168 0.246 NM_177543
PPAP2C
phosphatidic acid phosphatase type 2C
chr1_+_203444882 0.244 NM_002725
NM_201348
PRELP

proline/arginine-rich end leucine-rich repeat protein

chr19_+_50529276 0.242 ZNF473
zinc finger protein 473
chr20_+_12989616 0.237 NM_018327
SPTLC3
serine palmitoyltransferase, long chain base subunit 3
chrX_-_100307091 0.236 NM_001167970
NM_001167971
NM_001167972
NM_024917
TRMT2B



TRM2 tRNA methyltransferase 2 homolog B (S. cerevisiae)



chr11_-_118436591 0.235 NM_001168618
NM_020153
IFT46

intraflagellar transport 46 homolog (Chlamydomonas)

chr17_-_56296587 0.234 NM_017777
MKS1
Meckel syndrome, type 1
chr1_+_13736906 0.233 NM_001099852
PRAMEF20
PRAME family member 20
chr1_+_149754245 0.233 NM_000566
FCGR1A
Fc fragment of IgG, high affinity Ia, receptor (CD64)
chr4_+_108814419 0.233 NM_001136257
NM_152621
SGMS2

sphingomyelin synthase 2

chr3_-_196065243 0.233 NM_001204897
NM_001204898
NM_138461
TM4SF19


transmembrane 4 L six family member 19


chrX_+_8432870 0.230 NM_001001888
VCX3B
VCX3A
variable charge, X-linked 3B
variable charge, X-linked 3A
chr1_-_36851517 0.229 STK40
serine/threonine kinase 40
chr19_-_291335 0.229 NM_003712
NM_177526
PPAP2C

phosphatidic acid phosphatase type 2C

chr17_-_56296965 0.229 NM_001165927
MKS1
Meckel syndrome, type 1
chr11_-_9482009 0.227 LOC644656
uncharacterized LOC644656
chrX_-_6453158 0.227 NM_016379
VCX2
VCX3A
variable charge, X-linked 2
variable charge, X-linked 3A
chr14_+_60975937 0.223 NM_007374
SIX6
SIX homeobox 6
chr14_+_21945328 0.220 NM_014828
TOX4
TOX high mobility group box family member 4
chr2_-_56151273 0.219 NM_001039348
NM_001039349
EFEMP1

EGF containing fibulin-like extracellular matrix protein 1

chr12_-_6798419 0.218 ZNF384
zinc finger protein 384
chr11_-_118095708 0.216 NM_001098526
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr11_-_62475060 0.214 NM_001122955
BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr4_-_84255895 0.214 NM_001199830
HPSE
heparanase
chr1_-_184723952 0.214 EDEM3
ER degradation enhancer, mannosidase alpha-like 3
chr3_+_49027281 0.213 NM_177938
NM_177939
P4HTM

prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)

chr1_-_203154304 0.212 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr11_-_62474666 0.212 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr3_+_39509069 0.210 NM_182935
MOBP
myelin-associated oligodendrocyte basic protein
chr1_+_46806389 0.208 NM_199044
NSUN4
NOP2/Sun domain family, member 4
chr11_+_10472223 0.205 NM_000480
AMPD3
adenosine monophosphate deaminase 3
chr2_-_63815761 0.204 NM_015910
WDPCP
WD repeat containing planar cell polarity effector
chr1_+_61869699 0.204 NFIA
nuclear factor I/A
chr12_-_8218930 0.203 NM_004054
C3AR1
complement component 3a receptor 1
chr8_+_144102299 0.202 LY6E
lymphocyte antigen 6 complex, locus E
chr13_+_58205943 0.201 PCDH17
protocadherin 17
chr19_+_19322763 0.201 NM_004386
NCAN
neurocan
chr1_+_236686738 0.200 NM_006499
NM_201543
LGALS8

lectin, galactoside-binding, soluble, 8

chr16_+_30968614 0.200 NM_014712
SETD1A
SET domain containing 1A
chr4_-_70725792 0.198 NM_005420
SULT1E1
sulfotransferase family 1E, estrogen-preferring, member 1
chr9_+_137967088 0.196 NM_014279
NM_006334
OLFM1

olfactomedin 1

chr6_-_31981049 0.196 NM_032470
TNXB
tenascin XB
chr19_+_50529211 0.195 NM_001006656
NM_015428
ZNF473

zinc finger protein 473

chr14_+_96152753 0.194 NM_004918
TCL1B
T-cell leukemia/lymphoma 1B
chr20_+_19915716 0.193 RIN2
Ras and Rab interactor 2
chr13_+_52436116 0.192 NM_031290
CCDC70
coiled-coil domain containing 70
chrX_+_148626065 0.191 NM_001171909
CXorf40A
chromosome X open reading frame 40A
chr10_-_14646237 0.191 FAM107B
family with sequence similarity 107, member B

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
13.83 1.47e-03 GO:0060678 dichotomous subdivision of terminal units involved in ureteric bud branching
12.29 4.21e-03 GO:0048880 sensory system development
12.29 4.21e-03 GO:0048892 lateral line nerve development
12.29 4.21e-03 GO:0048895 lateral line nerve glial cell differentiation
12.29 4.21e-03 GO:0048925 lateral line system development
12.29 4.21e-03 GO:0048937 lateral line nerve glial cell development
12.29 4.21e-03 GO:0050935 iridophore differentiation
6.38 1.23e-02 GO:0007632 visual behavior
8.60 1.37e-02 GO:0048485 sympathetic nervous system development
1.17 2.07e-02 GO:0065007 biological regulation
10.06 2.10e-02 GO:0060600 dichotomous subdivision of an epithelial terminal unit
6.70 2.73e-02 GO:0008542 visual learning
1.18 2.76e-02 GO:0050789 regulation of biological process
1.56 3.03e-02 GO:0002376 immune system process
1.20 3.68e-02 GO:0050896 response to stimulus
9.22 4.01e-02 GO:0048846 axon extension involved in axon guidance
9.22 4.01e-02 GO:0090184 positive regulation of kidney development
5.53 4.63e-02 GO:0008306 associative learning

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.38 1.06e-02 GO:0044459 plasma membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.69 3.13e-02 GO:0043565 sequence-specific DNA binding
2.95 4.92e-02 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances